Office of Disease Prevention and Health Promotion

IID-32 Data Details

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IID-32 Increase the proportion of culture-confirmed TB patients with a positive nucleic acid amplification test (NAAT) result reported within 2 days of specimen collection

About the Data

Description of the data source, numerator, denominator, survey questions, and other relevant details about the national estimate.

Data Source:

National TB Surveillance System (NTSS); Centers for Disease Control and Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention (CDC/NCHHSTP)

Changed Since the Healthy People 2020 Launch:

Yes

Measure:

percent

Baseline (Year):

32.0 (2008)

Target:

77.0

Target-Setting Method:

Maintain consistency with national programs, regulations, policies, and laws.

Numerator:

Number of patients with a positive NAAT result within 2 days of specimen collection

Denominator:

Number of all the culture confirmed cases of tuberculosis

Comparable Healthy People 2010 Objective:

Adapted from HP2010 objective

Questions Used to Obtain the National Baseline Data:

From the National TB Surveillance System's standard case report form, Report of Verified Case of Tuberculosis (RVCT):

[NUMERATOR:]

Nucleic Acid Amplification Test Result (select one):

Positive
Negative
Not Done
Unknown
Indeterminate

For positive or negative results of nucleic acid amplification testing, enter the month, day, and year the first sputum specimen was collected.

For the first nucleic acid amplification test result reported positive for M. tuberculosis complex, enter the month, day, and year the result was reported by the laboratory.

Methodology Notes:

Nucleic acid amplification tests are capable of detecting Mycobacterium tuberculosis in a specimen within 48 hours of collection. Concerns regarding sensitivity, cost, quality control, availability and special expertise requirements have hindered widespread use of such tests. Upgrading TB laboratory capabilities and facilities, improving training in state-of-the-art mycobacteriology, and evaluating proficiency should better enable laboratories to apply these rapid tests to the diagnosis of TB.

Changes Between HP2010 and HP2020:

This objective differs from Healthy People 2010 objective 14-14 in that the measure was revised from "the mean number of days it takes each state health laboratory to confirm 75 percent of the most rapidly confirmed cases out of all its laboratory-confirmed cases of tuberculosis" to "the proportion of patients with a positive NAAT result within 2 days of specimen collection."

Revision History

Any change to the objective text, baseline, target, target-setting method or data source since the Healthy People 2020 launch.

Description of Changes Since the Healthy People 2020 Launch:

In 2013, the objective statement was revised from "Reduce the average time for laboratories to confirm and report tuberculosis cases" to "Increase the proportion of culture confirmed TB patients with a positive nucleic acid amplification test (NAAT) result reported within 2 days of specimen collection" in order to make the objective statement consistent with the desired direction and value label.

References

Additional resources about the objective

Starks, A.M., T.L. Dalton, F. Tyrrell, B. Metchock. “Use of Nucleic Acid Amplification Tests (NAAT) by U.S. Public Health Laboratories (PHL) for detection of Mycobacterium tuberculosis complex in Clinical Specimens”. Poster presented as part of the North American Region of the International Union Against TB and Lung Disease, Orlando, Florida, 11-13 March 2010.
Updated Guidelines for the Use of Nucleic Acid Amplification Tests in the Diagnosis of Tuberculosis. MMWR. January 16, 2009 / 58(01); 7-10.

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