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Evidence-Based Resource Summary

Strength of Evidence: 
4 out of 4
4 out of 4
Year Published: 

Statins to Prevent Cardiovascular Disease: Preventive Medication in Adults Ages 40 to 75 Years at Low Risk

Description of Resource: 
Although statin use may be beneficial for the primary prevention of cardiovascular disease (CVD) events in some adults with a 10-year CVD event risk of less than 10%, the likelihood of benefit is smaller, because of a lower probability of disease and uncertainty in individual risk prediction. Clinicians may choose to offer a low- to moderate-dose statin to certain adults without a history of CVD when all of the following criteria are met: 1) they are ages 40 to 75 years; 2) they have one or more CVD risk factors (dyslipidemia, diabetes, hypertension, or smoking); and 3) they have a calculated 10-year risk of a cardiovascular event of 7.5% to 10%. This is a C recommendation, which means the USPSTF recommends selectively offering or providing this service to individual patients based on professional judgment and patient preferences. There is at least moderate certainty that the net benefit is small.

Evidence-Based Resource Details

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Developed By: 
United States Preventive Services Task Force
Developer Type: 
Federal Government
Healthy People 2020 Topic Area(s): 
Heart Disease and Stroke
Older Adults
Resource Type: 
Systematic Review
U.S. Preventive Services Task Force. Statin Use for the Primary Prevention of Cardiovascular Disease in Adults: Preventive Medication [Internet]. 2016 Nov [cited 2017 Sept 8]. Available from: