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Evidence-Based Resource Summary

Strength of Evidence: 
4 out of 4
4 out of 4
Year Published: 

Rapid Diagnostic Tests versus Clinical Diagnosis for Managing People with Fever in Malaria Endemic Settings

Description of Resource: 
This systematic review examined the effects of rapid diagnostic tests (RDTs) for diagnosing malaria compared to relying on clinical symptoms alone. It identified 7 randomized controlled trials, which enrolled 17,505 people with fever. RDTs are simple diagnostic kits that do not require laboratory facilities or extensive training. In these trials, using RDTs had little or no effect on the number of people remaining unwell 4 to 7 days after treatment. However, using RDTs reduced the prescription of anti-malarial drugs by up to 75%. This reduction was highest where health workers only prescribed anti-malarials following a positive test, and where malaria was less common.

Evidence-Based Resource Details

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Developed By: 
Cochrane Review
Developer Type: 
Non-Federal Government
Healthy People 2020 Topic Area(s): 
Global Health
Healthy People 2020 Objectives: 
Resource Type: 
Systematic Review
Odaga J, Sinclair D, Lokong JA, Donegan S, Hopkins H, Garner P. Rapid diagnostic tests versus clinical diagnosis for managing people with fever in malaria endemic settings. Cochrane Database Syst Rev [Internet]. 2014 [cited 2017 12 5];(4):Article CD008998. doi: 10.1002/14651858.CD008998.pub2. Available from: