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Evidence-Based Resource Summary

Strength of Evidence: 
4 out of 4
4 out of 4
Year Published: 

Post-exposure Passive Immunization for Preventing Rubella and Congenital Rubella Syndrome

Description of Resource: 
One way of preventing rubella in people who come into contact with a contagious person is to inject them with antibodies from blood donations. This systematic review sought to evaluate whether this is effective and included 12 studies in high-income countries. Eleven studies compared injecting antibodies into the muscle or vein of participants to injecting salt water or giving no treatment. These studies found antibodies to be effective at preventing rubella. People given antibodies were 39% less likely to develop rubella than people not given antibodies. People who received the highest doses of antibodies were 80% less likely to develop rubella than people not given antibodies.

Evidence-Based Resource Details

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Developed By: 
Cochrane Review
Developer Type: 
Non-Federal Government
Healthy People 2020 Topic Area(s): 
Immunization and Infectious Diseases
Healthy People 2020 Objectives: 
Resource Type: 
Systematic Review
Young MK, Cripps AW, Nimmo GR, van Driel ML. Post-exposure passive immunisation for preventing rubella and congenital rubella syndrome. Cochrane Database Syst Rev [Internet]. 2015 [cited 2018 Jan 23];(9). Art. No.: CD010586. doi: 10.1002/14651858.CD010586.pub2. Available from: