Visit for the latest Coronavirus Disease (COVID-19) updates.

You are here

Evidence-Based Resource Summary

Strength of Evidence: 
4 out of 4
4 out of 4
Year Published: 

Opioid Agonist Treatment for Pharmaceutical Opioid Dependent People

Description of Resource: 
With the increased use of pharmaceutical opioids, dependence on them has also increased. Most treatment options are based on research conducted with people dependent on heroin and not on other types of opioids. This systematic review aimed to assess the effects of different treatments for pharmaceutical opioid dependence. It identified 6 randomized controlled trials involving 607 participants. It found that methadone and buprenorphine appeared equally effective. Treatment with buprenorphine appeared more effective than detoxification or psychological treatments. Due to the overall low to moderate quality of the evidence, further research is needed.

Evidence-Based Resource Details

help Learn more about EBR criteria
Developed By: 
Cochrane Review
Developer Type: 
Non-Federal Government
Healthy People 2020 Topic Area(s): 
Medical Product Safety
Healthy People 2020 Objectives: 
Resource Type: 
Systematic Review
Nielsen S, Larance B, Degenhardt L, Gowing L, Kehler C, Lintzeris N. Opioid agonist treatment for pharmaceutical opioid dependent people. Cochrane Database Syst Rev [Internet]. 2016 [cited 2018 Feb 28];(5). Art. No.: CD011117. doi: 10.1002/14651858.CD011117.pub2. Available from: