Once or Twice Daily versus Three Times Daily Amoxicillin With or Without Clavulanate for the Treatment of Acute Otitis Media
Description of Resource:
Acute middle ear infection (acute otitis media) is a very common disease in children and may cause pain and hearing loss. Delayed or ineffective treatment may lead to serious complications such as eardrum perforation, sensorineural hearing loss or the disease becoming chronic. Amoxicillin, with or without Clavulanate, is the most commonly used antibiotic for treating acute otitis media. To aid compliance, the dosing interval has been reduced to 1 or 2 daily doses from the conventional 3 or 4. This systematic review sought to assess the evidence for this change in recommendation and identified 5 randomized clinical trials comparing the 2 dosing schedules. Results showed that treating acute middle ear infection with both dosing schedules, with or without Clavulanate, have the same results.