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Evidence-Based Resource Summary

Strength of Evidence: 
4 out of 4
4 out of 4
Year Published: 

Immunotherapy (Oral and Sublingual) for Food Allergy to Fruits

Description of Resource: 
Immunotherapy is a possible long-term treatment for food allergy, including for food allergy to fruit. This treatment gives increasingly larger doses of an allergen over a period of time to reduce sensitivity to the allergen. This systematic review identified 2 studies. One looked at oral immunotherapy in adults with an allergy to apple, comparing it to no treatment. One looked at sublingual immunotherapy in adults with an allergy to peach, comparing it to a placebo. The study of apple allergy found participants who received the intervention were less sensitive to apple than people in the control group at 8 months. The study of peach allergy did not find a difference between groups. In both studies, there were more side effects in people receiving the treatment, but these were not serious. Overall, the quality of evidence is very low and more research is needed before we can tell if oral and sublingual therapy works for food allergy to fruits.

Evidence-Based Resource Details

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Developed By: 
Cochrane Library
Developer Type: 
Non-Federal Government
Healthy People 2020 Topic Area(s): 
Food Safety
Healthy People 2020 Objectives: 
Resource Type: 
Systematic Review
Yepes-Nuñez JJ, Zhang Y, Roqué i Figuls M, Bartra Tomas J, Reyes JM, Pineda de la Losa F, Enrique E. Immunotherapy (oral and sublingual) for food allergy to fruits. Cochrane Database Syst Rev [Internet]. 2015 [cited 2017 Oct 25];(11). doi: 10.1002/14651858.CD010522.pub2. Available from: