Immunotherapy (Oral and Sublingual) for Food Allergy to Fruits
Description of Resource:
Immunotherapy is a possible long-term treatment for food allergy, including for food allergy to fruit. This treatment gives increasingly larger doses of an allergen over a period of time to reduce sensitivity to the allergen. This systematic review identified 2 studies. One looked at oral immunotherapy in adults with an allergy to apple, comparing it to no treatment. One looked at sublingual immunotherapy in adults with an allergy to peach, comparing it to a placebo. The study of apple allergy found participants who received the intervention were less sensitive to apple than people in the control group at 8 months. The study of peach allergy did not find a difference between groups. In both studies, there were more side effects in people receiving the treatment, but these were not serious. Overall, the quality of evidence is very low and more research is needed before we can tell if oral and sublingual therapy works for food allergy to fruits.