Fixed-Dose Combinations of Drugs versus Single-Drug Formulations for Treating Pulmonary Tuberculosis
Description of Resource:
Tuberculosis (TB) is an important health problem, especially in developing countries. The treatment for pulmonary TB in new patients includes 4 oral medicines taken for 6 months, sometimes as fixed-dose combinations (FDCs) that are combined in 1 tablet, or taken separately as single-drug formulations. This systematic review assessed the efficacy, safety, and acceptability of FDCs compared with single-drug formulations for treating people with newly diagnosed pulmonary TB. It identified 13 randomized controlled trials that enrolled 5,824 people and found that fixed-dose combinations have similar efficacy to single-drug formulations for treating people with newly diagnosed pulmonary TB.