Fibrates for Secondary Prevention of Cardiovascular Disease and Stroke
Description of Resource:
Fibrates are a class of drugs that work by positively influencing fats in the blood. This systematic review sought to assess the effect of fibrates for the prevention of major events including heart attacks and strokes in people with existing circulatory disease. This review identified 13 clinical trials and found that when compared primarily to placebo, fibrates can be effective for prevention of major events. However, this beneficial effect relies on the inclusion of data on clofibrates, a drug that was discontinued in 2002 because of safety concerns. There is no good evidence to support the use of currently available fibrates in the prevention of future heart attacks, strokes, and circulatory disease death in people with existing circulatory disease.