Antiretroviral Therapy for Prevention of HIV Transmission in HIV-Discordant Couples
Description of Resource:
Antiretroviral drugs can prevent transmission of HIV from an infected sexual partner to an uninfected one. This systematic review sought to determine if antiretroviral therapy (ART) use in the partner infected with HIV in an HIV-discordant couple is associated with lower risk of HIV transmission to the uninfected partner compared to the risk of transmission in untreated discordant couples. This review identified 1 randomized controlled trial and 9 observational studies and found that in couples in which the infected partner was being treated with ART, the uninfected partner's risk of infection decreased by at least 40%.