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Evidence-Based Resource Summary

Strength of Evidence: 
4 out of 4
4 out of 4
Year Published: 

Antiretroviral Therapy for Prevention of HIV Transmission in HIV-Discordant Couples

Description of Resource: 
Antiretroviral drugs can prevent transmission of HIV from an infected sexual partner to an uninfected one. This systematic review sought to determine if antiretroviral therapy (ART) use in the partner infected with HIV in an HIV-discordant couple is associated with lower risk of HIV transmission to the uninfected partner compared to the risk of transmission in untreated discordant couples. This review identified 1 randomized controlled trial and 9 observational studies and found that in couples in which the infected partner was being treated with ART, the uninfected partner's risk of infection decreased by at least 40%.

Evidence-Based Resource Details

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Developed By: 
Cochrane Review
Developer Type: 
Non-Federal Government
Healthy People 2020 Topic Area(s): 
Healthy People 2020 Objectives: 
Resource Type: 
Systematic Review
Anglemyer A, Rutherford GW, Horvath T, Baggaley RC, Egger M, Siegfried N. Antiretroviral therapy for prevention of HIV transmission in HIV-discordant couples. Cochrane Database Syst Rev [Internet]. 2013 [cited 2018 Jan 23];(4). Art. No.: CD009153. doi: 10.1002/14651858.CD009153.pub3. Available from: