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Perinatal Hepatitis B Prevention Program


The Perinatal Hepatitis B Prevention Program (PHBPP) was created because Congress recognized the need to foster efforts to prevent perinatal HBV transmission and made resources available to develop and implement programs. CDC annually awards funds to support perinatal hepatitis B prevention programs among 64 immunization grantees. The mission of these programs is the prevention of hepatitis B transmission from infected mothers to infants through the identification of hepatitis B surface antigen (HBsAg)-positive pregnant women and their infants and the case management of the infants and household and sexual contacts.

The goals of the PHBPP are to (1) identify HBsAg-positive pregnant women, (2) identify and manage infants born to HBsAg-positive mothers and to mothers without HBsAg test results until maternal status is determined, (3) insure that delivery hospitals administer recommended post-exposure prophylaxis (hepatitis B immune globulin HBIG and hepatitis B vaccine), and (4) insure infants complete the hepatitis B vaccine series and receive post-vaccination testing.

Centers for Disease Control and Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention
Data Years Available: 
1990-present, although not all databases are still available.
Mode of Collection: 
Surveillance data: active data collection
Selected Content: 
Each program reports: – the number of HBsAg-positive pregnant women identified and number of these women who are case managed – the number of infants born to HBsAg-positive pregnant women identified and the number who are case managed – the number and proportion of infants born to HBsAg-positive mothers receiving postexposure immunoprophylaxis at birth, completion of the vaccination series by 8 and 12 months of age, completing post-vaccination serologic testing for HBsAg and for anti-HBs with a result known before 24 months of age – the number of infants lost to follow-up
Population Covered: 
Infants born to women with hepatitis B infection during pregnancy (includes both acute and chronic hepatitis B infection)

Collected data from case management records.

Response Rates and Sample Size: 

Approximately 25,000 infants are born to HBsAg-positive women annually in the United States. Among 64 public health jurisdictions, about 50% of the estimated HBsAg-positive women nationally are identified by Perinatal Hepatitis B Prevention Programs (PHBPPs). From 1994-2008, the percentage of PHBPP-managed infants who received post-vaccination serologic testing more than doubled from 25.1% to 55.7%. The incidence of chronic hepatitis B infection among those infants decreased significantly.

Interpretation Issues: 

Data are self-reported by PHBPP and have not verified.


Smith EA, Jacques-Carroll L, Walker TY, Sirotkin B, Murphy TV. The National Perinatal Hepatitis B Prevention Program, 1994-2008. Pediatrics 2012 Apr;129(4):609-16. doi: 10.1542/peds.2011-2866. Epub 2012 Mar 26.

CDC. Postvaccination serologic testing results for infants aged ≤24 months exposed to hepatitis B virus at birth – United States, 2008-2011. MMWR 2012;61(38):768-71.