Estimates of alcohol-related deaths are calculated using pre-determined estimates of Alcohol-Attributable Fractions (AAFs)—that is, the proportion of deaths from various causes that are due to alcohol. These AAFs are then multiplied by the number of deaths caused by a specific condition (e.g., liver cancer) to obtain the number of alcohol-attributable deaths. The cutpoints used to define different levels of average daily alcohol consumption (i.e., low, medium, and high) were specified in the meta-analyses that were used to obtain risk estimates for a given condition. These cutpoints were typically reported as grams of alcohol per day, and then converted into drinks per day, using a 13.7 gram per drink conversion factor. A description of the ARDI software is available on CDCs website.